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10 Questions Hospital Pharmacy Leaders Should Ask Before Investing in RFID Automation

Shot of a mature pharmacist writing on a clipboard in a pharmacy

Hospital pharmacies continue to face compounding pressures to do more with less, all while complying with strict regulations. Pharmacists—while facing pharmacy technician staffing shortages—are responsible for reducing medication waste, improving medication inventory accuracy, and navigating critical drug shortages. 

RFID pharmacy automation can help address these challenges. However, not all RFID solutions offer the same capabilities. Before selecting an RFID medication inventory management platform, pharmacy leaders should ask important operational questions during vendor evaluations and during virtual or in-person demonstrations. 

The following questions are based on real-world conversations with hospital pharmacy directors, pharmacy managers, and health system leaders evaluating RFID automation in 2026.

1. Can the RFID system scale with our inventory volume?

Many hospital pharmacies process thousands of medications daily, which can be extremely time-consuming for clinical staff—especially if they’re still relying on manual counts. 

Questions to ask vendors 

  • How many medications can be scanned at once while maintaining read accuracy?
  • Does scanning speed change as inventory volume increases?
  • Can the software support centralized pharmacy operations, such as a Consolidated Services Center (CSC), in case our health system decides to expand or adopt this model? 

A system that slows down during high-volume workflows can create bottlenecks and reduce staff adoption. Make sure to ask about “phantom reads” or the frequency with which the vendor’s customers experience “dead tags.” 

What to look for

  • Bulk scanning and support for large medication batches (including replenished kits and trays, multiple boxes of medications)
  • Consistent scan times
  • Scalability across sites, including stand-alone clinics, hospitals, or satellite pharmacies/storage

Vendor solution example

Intelliguard’s Mira Prep™ pharmacy station can accurately scan over 800 medications simultaneously within the enclosure, depending on package size. Inventory can be scanned in bulk (kits, trays, tackle boxes, pre-tagged medications, boxes of medications) without requiring item-by-item processing, which reduces the potential for human error.

2. Will the RFID solution work with source-tagged medications?

The healthcare industry is moving toward pre-tagged medications, meaning the RFID tags are already embedded in the medication packaging. Tagging is handled entirely by the drug manufacturer or distributor.  

Examples include:

Questions to ask vendors

  • Can the system read all GS1-compatible tags without first uploading data to a registry?
  • Is it able to read manufacturer-tagged or source-tagged medications?
  • Are proprietary RFID tags required by the vendor, or can the system read any tag?

What to look for

  • GS1 compliance, meaning the RFID tag includes the following data:
    • Lot number or batch number
    • Expiration date
    • National Drug code (NDC) or Global Trade Item Number (GTIN)
    • Unique serial number
  • Support for source-tagged medications
  • Interoperability with future RFID initiatives

Vendor solution example

Mira Prep supports GS1 standards and can read RFID tags from manufacturers and distributors without requiring pharmacies to rely exclusively on proprietary flag tags.

3. Does the RFID platform support flexible medication workflows?

Because national drug shortages and supply chain delays are so common, hospital pharmacies need workflows that can quickly adapt to medication substitutions. This may include: 

  • Switching to a different vial size (5 mL versus 10 mL)
  • Using a different package format (vial versus pre-filled syringe)
  • Managing alternative presentations of the same medication (503B compounded medications)

Questions to ask vendors

  • Can medications be substituted within the system’s electronic drug formulary? (e.g., item-level substitutions)
  • Is substitution limited to a one-to-one replacement?
  • Can pharmacists edit incorrectly encoded medications in the case of a mistake?
  • Can edits be made in bulk, or does it need to be done one by one?

Because medication inventory is constantly changing, it is critical that pharmacists choose an RFID medication management system that offers workflow flexibility. Rigid workflows can increase waste and create unnecessary work.

What to look for

  • Drug formulary flexibility
  • Bulk editing capabilities
  • Customizable user permission controls
  • Inventory correction tools (e.g., the ability to have multiple super users within the system)

Vendor solution example

With Mira Prep, authorized users can easily edit encoded information, correct errors, and update multiple medication batches simultaneously.

4. How simple is the medication encoding process?

Successful technology adoption often depends on ease of use. Because pharmacies are often understaffed, they are looking for ease of use to avoid adding further steps or time to their workflows. Pharmacy teams need encoding (or tag association) workflows that are fast and easy to learn. 

Questions to ask vendors

  • How are medications encoded or associated within the system? Can your implementation team help with this?
  • How long does encoding take?
  • What happens when the system encounters an unknown item?

What to look for

  • Intuitive and simple user interface (this can be seen during a virtual or in-person product demonstration)
  • Fast encoding process
    • Ask about the number of steps/clicks from start to finish
  • Exception management tools

Simple, streamlined workflows improve consistency and efficiency. 

5. How does RFID help reduce expired medication waste?

Expired medications are a significant source of waste, resulting in thousands of dollars in losses every year. Overstocking, inaccurate PAR levels, and limited inventory visibility can all contribute to medications expiring before use. RFID helps hospitals track expiration dates in real time and identify medications that require attention before they become waste, which helps with cost savings as well as time savings for clinical staff. 

Questions to ask vendors

  • Can expiration alerts be customized to align with our state or health system policies?
  • How are expiring medications identified?
  • Can expiry or recall alerts be configured by location?

Hospitals may have different compliance requirements and inventory management policies. 

What to look for

  • Configurable notifications
  • Proactive and real-time expiration tracking
  • Automated alerts
  • Reporting capabilities

Vendor Solution Example 

With Intelliguard’s Mira Prep pharmacy station, pharmacy teams can configure expiration alerts at 30-, 60-, or 90-day intervals to proactively manage inventory. Additionally, pharmacy technicians have real-time traceability with Logbook, which shows where soon-expiring items are located across units and sites so that teams can reallocate them before they expire.

6. Can the system effectively manage drug shortages and recalls?

Drug shortages continue to impact hospitals around the globe. Additionally, manual drug recall management is extremely time-consuming for clinical staff.  

Questions to ask vendors

  • How does the system identify national drug shortages?
  • Are recall notifications automated?
  • Can affected inventory be located immediately across all points of care?

Large health systems may have medications spread across multiple units and sites, such as: 

  • 20+ operating rooms (ORs)
  • Adult and pediatric crash carts
  • Automated dispensing cabinets (ADCs)
  • Nursing units across the ICU, ER, Med/Surg, Oncology, and more
  • Satellite pharmacy or stand-alone Consolidated Services Centers (CSC)
  • Are recall notifications automated?
  • Can affected inventory be located immediately across all points of care?

What to look for

  • Recall notifications (be sure to ask which sources the system pulls from)
  • Drug shortage visibility
  • Inventory search capabilities

Vendor Solution Example 

Mira Prep incorporates RxNorm and ASHP data, Tallman lettering support to differentiate lookalike soundalike (LASA) drugs, and recall information from industry databases. 

7. Will the RFID platform integrate with existing pharmacy automation?

Many hospitals already use some form of automation, including: 

  • Narcotic vaults and carousels
  • Picking robots
  • Automated dispensing cabinets
  • Inventory management software

Questions to ask vendors

  • Can the system integrate with existing automation?
  • Will current workflows need to change?
  • Can data be shared across vendors and their respective systems, as well as the electronic health record (EHR)?

New technology should strengthen existing investments rather than replace them.

What to look for

  • Ability to seamlessly integrate with existing automation systems
  • Data interoperability (via HL7 feeds)
  • Health system scalability

Vendor Solution Example 

Intelliguard’s hardware and software solutions can integrate with pharmacy carousels and robotic systems to support connected inventory workflows. 

8. How reliable is RFID technology in pharmacies?

Reliability is one of the main components that pharmacy teams will evaluate when choosing automation. And data reliability enables confident, real-time decision-making from the inpatient pharmacy to supply chain management. 

Questions to ask vendors

  • What happens when an RFID tag fails?
  • How frequently do tag failures occur?
  • How are damaged tags identified?

What to look for

  • Durable RFID tags that won’t cover important medication data on a vial or packaging
  • Strong adhesive
  • High read accuracy
  • Proven real-world performance

Vendor Solution Example 

Intelliguard RFID flag tags are about 2 inches long and have undergone rigorous testing to withstand routine pharmacy handling, refrigeration, and condensation. Additionally, the patented RFID technology inside the Mira Prep pharmacy station provides over 99.9% read accuracy.

9. Can RFID tags obstruct medication labels?

Small-volume medications can create tagging challenges.

Questions to ask vendors

  • Can clinicians still read medication labels once the RFID tag is attached?
  • Are your flag tags designed for small vials, like 1 mL or 5 mL? (Ask to see an example of what the tags look like once attached to a small vial)
  • Will tags interfere with barcode scanning?
    • Do the tags cover important drug information that’s included on the label?

Medication identification must remain visible. 

What to look for

  • Clear, adhesive materials
  • Small tag footprint (ask for a spec sheet)
  • Support for multiple package formats

Vendor solution example

Intelliguard’s clear flag tag design helps maintain visibility of critical medication information on small vials, ampules, syringes, and IV bags.

10. Does the RFID vendor support future pharmacy automation initiatives?

Technology decisions should support long-term pharmacy strategies. As pharmacy is now at the center of financial performance and enterprise decision-making across health systems, it is critical that decision-makers treat automation as an investment rather than a point solution. 

Questions to ask vendors

  • What is the vendor’s roadmap?
    • Ask them to describe any products/solutions they’re working on based on industry or customer demand
  • How does the solution support DSCSA readiness and additional hospital compliance requirements?
  • Can the platform expand across the health system?

Health systems need solutions that can evolve alongside operational requirements. 

What to look for

  • Standards-based architecture
  • Health system scalability
    • How hard is it to add this automation to a new site or location opening next year?
  • Interoperability
  • Ongoing innovation

Intelliguard supports open interoperability and GS1 standards to enable shared data language across RFID vendors, drug manufacturers, and health systems. The Mira Ecosystem creates a scalable, interconnected network that enhances end-to-end medication visibility. 
 
By connecting trusted data across the entire medication lifecycle, healthcare providers and supply chain partners can operate with greater precision and confidence, ultimately advancing the industry toward a smarter, safer, and more sustainable future. 

Conclusion 

Choosing an RFID pharmacy automation platform isn’t about replacing clinicians. It’s about giving pharmacy teams better visibility, faster workflows, and more reliable inventory management. 

By asking the right questions during vendor evaluations, hospital pharmacy leaders can identify RFID solutions that reduce waste, improve operational efficiency, support regulatory compliance, and scale across the health system. As RFID adoption continues to grow, standards-based, interoperable platforms will be best positioned to support future pharmacy automation initiatives.